Cognition in Movement Disorders: Where Can We Hope to be in Ten Years?
Identifieur interne : 000637 ( Main/Exploration ); précédent : 000636; suivant : 000638Cognition in Movement Disorders: Where Can We Hope to be in Ten Years?
Auteurs : David Burn [Royaume-Uni] ; Daniel Weintraub [États-Unis] ; Bernard Ravina [États-Unis] ; Irene Litvan [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.
English descriptors
- KwdEn :
- Animals, Biological Markers, Cognition (physiology), Cognition Disorders (complications), Cognition Disorders (diagnosis), Cognition Disorders (therapy), Dementia (complications), Dementia (diagnosis), Dementia (therapy), Humans, Movement Disorders (diagnosis), Movement Disorders (etiology), Movement Disorders (therapy).
- MESH :
- chemical : Biological Markers.
- complications : Cognition Disorders, Dementia.
- diagnosis : Cognition Disorders, Dementia, Movement Disorders.
- etiology : Movement Disorders.
- physiology : Cognition.
- therapy : Cognition Disorders, Dementia, Movement Disorders.
- Animals, Humans.
Abstract
Cognitive impairment and dementia associated with movement disorders represent a major management challenge and area of unmet need. This article has focused upon Parkinson’s disease as an exemplar condition, but many of the roadblocks and efforts to overcome these are applicable, in a general sense, to other disorders. Short of a “penicillin moment”—a chance discovery or piece of unintended good fortune—progress is likely to be incremental. Cognitive therapies may end up being multiple and possibly multimodal, parallel with the cancer therapy field. Ultimately, benefit for one condition may extend to others as commonality in protein aggregation, synergistic pathological effects between proteins, and pathological spread emerges.
Url:
DOI: 10.1002/mds.25850
PubMed: 24757118
PubMed Central: 4371593
Affiliations:
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Le document en format XML
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qualifier="physiology" xml:lang="en"><term>Cognition</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Cognition Disorders</term><term>Dementia</term><term>Movement Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Cognitive impairment and dementia associated with movement disorders represent a major management challenge and area of unmet need. 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